Delir und Delirmanagement bei kritisch kranken Patienten (2024)

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Zurück zum Zitat Pauley E, Lishmanov A, Schumann S et al (2015) Delirium is a robust predictor of morbidity and mortality among critically ill patients treated in the cardiac intensive care unit. Am Heart J 170:79–86CrossRefPubMed Pauley E, Lishmanov A, Schumann S etal (2015) Delirium is a robust predictor of morbidity and mortality among critically ill patients treated in the cardiac intensive care unit. Am HeartJ 170:79–86CrossRefPubMed

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Zurück zum Zitat Peterson JF, Pun BT, Dittus RS et al (2006) Delirium and its motoric subtypes: a study of 614 critically ill patients. J Am Geriatr Soc 54:479–484CrossRefPubMed Peterson JF, Pun BT, Dittus RS etal (2006) Delirium and its motoric subtypes: a study of 614critically ill patients. JAm Geriatr Soc 54:479–484CrossRefPubMed

Zurück zum Zitat Ouimet S, Kavanagh BP, Gottfried SB et al (2007) Incidence, risk factors, and consequences of ICU delirium. Intensive Care Med 33:66–73CrossRefPubMed Ouimet S, Kavanagh BP, Gottfried SB etal (2007) Incidence, risk factors, and consequences of ICU delirium. Intensive Care Med 33:66–73CrossRefPubMed

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Zurück zum Zitat van den Boogaard M, Schoonhoven L, Evers AW et al (2012) Delirium in critically ill patients: impact on long-term health related quality of life and cognitive functioning. Crit Care Med 40(1):112–118CrossRefPubMed van den Boogaard M, Schoonhoven L, Evers AW etal (2012) Delirium in critically ill patients: impact on long-term health related quality of life and cognitive functioning. Crit Care Med 40(1):112–118CrossRefPubMed

Zurück zum Zitat Shehabi Y, Rikker RR, Bokesch PM et al (2010) Delirium duration and mortality in lightly sedated, mechanically ventilated intensive care unit patients. Crit Care Med 38:2311–2318CrossRefPubMed Shehabi Y, Rikker RR, Bokesch PM etal (2010) Delirium duration and mortality in lightly sedated, mechanically ventilated intensive care unit patients. Crit Care Med 38:2311–2318CrossRefPubMed

Zurück zum Zitat Girard TD, Shintani AK, Jackson JC et al (2007) Risk factors for posttraumatic stress disorder symptoms following critical illness requiring mechanical ventilation: a prospective cohort study. Crit Care 11:R28CrossRefPubMedPubMedCentral Girard TD, Shintani AK, Jackson JC etal (2007) Risk factors for posttraumatic stress disorder symptoms following critical illness requiring mechanical ventilation: a prospective cohort study. Crit Care 11:R28CrossRefPubMedPubMedCentral

Zurück zum Zitat van Eijk MM, van Marum RJ, Klijn IA, de Wit N, Kesecioglu J, Slooter AJ (2009) Comparison of delirium assessment tools in a mixed intensive care unit. Crit Care Med 37:1881–1885CrossRefPubMed van Eijk MM, van Marum RJ, Klijn IA, de Wit N, Kesecioglu J, Slooter AJ (2009) Comparison of delirium assessment tools in a mixed intensive care unit. Crit Care Med 37:1881–1885CrossRefPubMed

Zurück zum Zitat Ely EW, Inouye SK, Bernard GR et al (2001) Delirium in mechanically ventilated patients: validity and reliability of the Confusion Assessment Method for the Intensive Care Unit (CAM-ICU). JAMA 286:2703–2710CrossRefPubMed Ely EW, Inouye SK, Bernard GR etal (2001) Delirium in mechanically ventilated patients: validity and reliability of the Confusion Assessment Method for the Intensive Care Unit (CAM-ICU). JAMA 286:2703–2710CrossRefPubMed

Zurück zum Zitat Bergeron N, Dubois MJ, Dumont M, Dial S, Skrobik Y (2001) Intensive Care Delirium Screening Checklist: evaluation of a new screening tool. Intensive Care Med 27:859–864CrossRefPubMed Bergeron N, Dubois MJ, Dumont M, Dial S, Skrobik Y (2001) Intensive Care Delirium Screening Checklist: evaluation of a new screening tool. Intensive Care Med 27:859–864CrossRefPubMed

Zurück zum Zitat Vasilevskis EE, Morandi A, Boehm L et al (2011) Delirium and sedation recognition using validated instruments: reliability of bedside intensive care unit nursing assessments from 2007 to 2010. J Am Geriatr Soc 59:(Suppl 2):S249–S255CrossRefPubMedPubMedCentral Vasilevskis EE, Morandi A, Boehm L etal (2011) Delirium and sedation recognition using validated instruments: reliability of bedside intensive care unit nursing assessments from 2007 to 2010. JAm Geriatr Soc 59:(Suppl 2):S249–S255CrossRefPubMedPubMedCentral

Zurück zum Zitat Reade MC, Eastwood GM, Peck L, Bellomo R, Baldwin I (2011) Routine use of the Confusion Assessment Method for the Intensive Care Unit (CAM-ICU) by bedside nurses may underdiagnose delirium. Crit Care Resusc 13:217–224PubMed Reade MC, Eastwood GM, Peck L, Bellomo R, Baldwin I (2011) Routine use of the Confusion Assessment Method for the Intensive Care Unit (CAM-ICU) by bedside nurses may underdiagnose delirium. Crit Care Resusc 13:217–224PubMed

Zurück zum Zitat Pun BT, Dunn J (2007) The sedation of critically ill adults – part 1: assessment: the first in a two-part series focuses on assessing sedated patients in the ICU. Am J Nurs 107:40–48 Pun BT, Dunn J (2007) The sedation of critically ill adults – part1: assessment: the first in a two-part series focuses on assessing sedated patients in the ICU. Am J Nurs 107:40–48

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Zurück zum Zitat Inouye SK, Bogardus ST Jr, Charpentier PA et al (1999) A multicomponent intervention to prevent delirium in hospitalized older adults. N Engl J Med 340(9):669–676CrossRefPubMed Inouye SK, Bogardus ST Jr, Charpentier PA etal (1999) A multicomponent intervention to prevent delirium in hospitalized older adults. NEngl J Med 340(9):669–676CrossRefPubMed

Zurück zum Zitat Vidán MT, Sánchez E, Alonso M, Montero B, Ortiz J, Serra JA (2009) An intervention integrated into daily clinical practice reduces the incidence of delirium during hospitalization in elderly patients. J Am Geriatr Soc 57(11):2029–2036CrossRefPubMed Vidán MT, Sánchez E, Alonso M, Montero B, Ortiz J, Serra JA (2009) An intervention integrated into daily clinical practice reduces the incidence of delirium during hospitalization in elderly patients. JAm Geriatr Soc 57(11):2029–2036CrossRefPubMed

Zurück zum Zitat Rivosecchi RM, Smithburger PL, Svec S et al (2015) Non-pharmacological interventions to prevent delirium: an evidence based systematic review. Crit Care Nurse 35(1):39–51CrossRefPubMed Rivosecchi RM, Smithburger PL, Svec S etal (2015) Non-pharmacological interventions to prevent delirium: an evidence based systematic review. Crit Care Nurse 35(1):39–51CrossRefPubMed

Zurück zum Zitat Inouye SK, Baker DI, Fugal P et al (2006) Dissemination of the hospital elder life program: implementation, adaptation, and successes. J Am Geriatr Soc 54:1492–1499CrossRefPubMed Inouye SK, Baker DI, Fugal P etal (2006) Dissemination of the hospital elder life program: implementation, adaptation, and successes. JAm Geriatr Soc 54:1492–1499CrossRefPubMed

Zurück zum Zitat van den Boogaard M, Pickkers P, Slooter AJ et al (2012) Development and validation of PRE-DELIRIC (PREdiction of DELIRium in ICU patients) delirium prediction model for intensive care patients: observational multicentre study. BMJ 344:e420CrossRefPubMedPubMedCentral van den Boogaard M, Pickkers P, Slooter AJ etal (2012) Development and validation of PRE-DELIRIC (PREdiction of DELIRium in ICU patients) delirium prediction model for intensive care patients: observational multicentre study. BMJ 344:e420CrossRefPubMedPubMedCentral

Zurück zum Zitat Tabet N, Hudson S, Sweeney V et al (2005) An educational intervention can prevent delirium on acute medical wards. Age Ageing 34(2):152–156CrossRefPubMed Tabet N, Hudson S, Sweeney V etal (2005) An educational intervention can prevent delirium on acute medical wards. Age Ageing 34(2):152–156CrossRefPubMed

Zurück zum Zitat Inouye SK, Bogardus ST, Charpentier PA et al (1999) A multicomponent intervention to prevent delirium in hospitalized older patients. N Engl J Med 340:669–676CrossRefPubMed Inouye SK, Bogardus ST, Charpentier PA etal (1999) A multicomponent intervention to prevent delirium in hospitalized older patients. NEngl J Med 340:669–676CrossRefPubMed

Zurück zum Zitat Schweickert WD, Pohlman MC, Pohlman AS et al (2009) Early physical and occupational therapy in mechanically ventilated, critically ill patients: a randomised controlled trial. Lancet 373(9678):1874–1882CrossRefPubMed Schweickert WD, Pohlman MC, Pohlman AS etal (2009) Early physical and occupational therapy in mechanically ventilated, critically ill patients: a randomised controlled trial. Lancet 373(9678):1874–1882CrossRefPubMed

Zurück zum Zitat Inouye SK, Bogardus ST, Williams CS et al (2003) The role of adherence on the effectiveness of nonpharmacologic interventions. Arch Intern Med 163:958–964CrossRefPubMed Inouye SK, Bogardus ST, Williams CS etal (2003) The role of adherence on the effectiveness of nonpharmacologic interventions. Arch Intern Med 163:958–964CrossRefPubMed

Zurück zum Zitat Hu RF, Jiang XY, Hegadoren KM et al (2015) Effects of earplugs and eye masks combined with relaxing music on sleep, melatonin and cortisol levels in ICU patients: a randomized controlled trial. Crit Care Med 19:115 Hu RF, Jiang XY, Hegadoren KM etal (2015) Effects of earplugs and eye masks combined with relaxing music on sleep, melatonin and cortisol levels in ICU patients: a randomized controlled trial. Crit Care Med 19:115

Zurück zum Zitat Kress P, Pohlman AS, O’Connor MF et al (2000) Daily interruption of sedative infusions in critically ill patients undergoing mechanical ventilation. N Engl J Med 342:1471–1477CrossRefPubMed Kress P, Pohlman AS, O’Connor MF etal (2000) Daily interruption of sedative infusions in critically ill patients undergoing mechanical ventilation. NEngl J Med 342:1471–1477CrossRefPubMed

Zurück zum Zitat Girard TD, Kress JP, Fuchs BD et al (2008) Efficacy and safety of a paired sedation and ventilator weaning protocol for mechanically ventilated patients in intensive care (Awakening and Breathing Controlled trial): a randomized controlled trial. Lancet 371:126–134CrossRefPubMed Girard TD, Kress JP, Fuchs BD etal (2008) Efficacy and safety of a paired sedation and ventilator weaning protocol for mechanically ventilated patients in intensive care (Awakening and Breathing Controlled trial): a randomized controlled trial. Lancet 371:126–134CrossRefPubMed

Zurück zum Zitat Kalisvaart KJ, de Jonghe JF, Bogaards MJ et al (2005) Haloperidol prophylaxis for elderly hip-surgery patients at risk for delirium: a randomized placebo-controlled study. J Am Geriatr Soc 53:1658–1666CrossRefPubMed Kalisvaart KJ, de Jonghe JF, Bogaards MJ etal (2005) Haloperidol prophylaxis for elderly hip-surgery patients at risk for delirium: a randomized placebo-controlled study. JAm Geriatr Soc 53:1658–1666CrossRefPubMed

Zurück zum Zitat Wang W, Li HL, Wang DX et al (2012) Haloperidol prophylaxis decreases delirium incidence in elderly patients after noncardiac surgery: a randomized controlled trial. Crit Care Med 40:731–739CrossRefPubMed Wang W, Li HL, Wang DX etal (2012) Haloperidol prophylaxis decreases delirium incidence in elderly patients after noncardiac surgery: a randomized controlled trial. Crit Care Med 40:731–739CrossRefPubMed

Zurück zum Zitat Prakanrattana U, Prapaitrakool S (2007) Efficacy of risperidone for prevention of postoperative delirium in cardiac surgery. Anaesth Intensive Care 35:714–719PubMed Prakanrattana U, Prapaitrakool S (2007) Efficacy of risperidone for prevention of postoperative delirium in cardiac surgery. Anaesth Intensive Care 35:714–719PubMed

Zurück zum Zitat Riker RR, Shehabi Y, Bokesch PM et al (2009) Dexmedetomidine vs midazolam for sedation of critically ill patients: a randomized trial. JAMA 301:489–499CrossRefPubMed Riker RR, Shehabi Y, Bokesch PM etal (2009) Dexmedetomidine vs midazolam for sedation of critically ill patients: a randomized trial. JAMA 301:489–499CrossRefPubMed

Zurück zum Zitat Pandharipande PP, Pun BT, Herr DL et al (2007) Effect of sedation with dexmedetomidine vs lorazepam on acute brain dysfunction in mechanically ventilated patients: the MENDS randomized controlled trial. JAMA 298:2644–2653CrossRefPubMed Pandharipande PP, Pun BT, Herr DL etal (2007) Effect of sedation with dexmedetomidine vs lorazepam on acute brain dysfunction in mechanically ventilated patients: the MENDS randomized controlled trial. JAMA 298:2644–2653CrossRefPubMed

Zurück zum Zitat Jakob SM, Ruokonen E, Grounds RM et al (2012) Dexmedetomidine vs midazolam or propofol for sedation during prolonged mechanical ventilation: two randomized controlled trials. JAMA 307:1151–1160CrossRefPubMed Jakob SM, Ruokonen E, Grounds RM etal (2012) Dexmedetomidine vs midazolam or propofol for sedation during prolonged mechanical ventilation: two randomized controlled trials. JAMA 307:1151–1160CrossRefPubMed

Zurück zum Zitat Devlin JW, Roberts RJ, Fong JJ et al (2010) Efficacy and safety of quetiapine in critically ill patients with delirium: a prospective, multicenter, randomized, doubleblind, placebo-controlled pilot study. Crit Care Med 38:419–427CrossRefPubMed Devlin JW, Roberts RJ, Fong JJ etal (2010) Efficacy and safety of quetiapine in critically ill patients with delirium: a prospective, multicenter, randomized, doubleblind, placebo-controlled pilot study. Crit Care Med 38:419–427CrossRefPubMed

Zurück zum Zitat Girard TD, Pandharipande PP, Carson SS et al (2010) Feasibility, efficacy, and safety of antipsychotics for intensive care unit delirium: the MIND randomized, placebo-controlled trial. Crit Care Med 38:428–437CrossRefPubMedPubMedCentral Girard TD, Pandharipande PP, Carson SS etal (2010) Feasibility, efficacy, and safety of antipsychotics for intensive care unit delirium: the MIND randomized, placebo-controlled trial. Crit Care Med 38:428–437CrossRefPubMedPubMedCentral

Zurück zum Zitat Reade MC, O’Sullivan K, Bates S, Goldsmith D, Ainslie WR, Bellomo R (2009) Dexmedetomidine vs. haloperidol in delirious, agitated, intubated patients: a randomised open-label trial. Crit Care 13:R75CrossRefPubMedPubMedCentral Reade MC, O’Sullivan K, Bates S, Goldsmith D, Ainslie WR, Bellomo R (2009) Dexmedetomidine vs. haloperidol in delirious, agitated, intubated patients: a randomised open-label trial. Crit Care 13:R75CrossRefPubMedPubMedCentral